Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.

نویسندگان

  • Norased Nasongkla
  • Erik Bey
  • Jimin Ren
  • Hua Ai
  • Chalermchai Khemtong
  • Jagadeesh Setti Guthi
  • Shook-Fong Chin
  • A Dean Sherry
  • David A Boothman
  • Jinming Gao
چکیده

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

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عنوان ژورنال:
  • Nano letters

دوره 6 11  شماره 

صفحات  -

تاریخ انتشار 2006